Search This Blog

Friday, May 7, 2010

Signature mucosa of allergic rhinitis

How different are persistent allergic rhinitis and intermittent allergic rhinitis? As it turns out, not much and quite a lot. Liu et al (Allergy 2010, doi: 10.1111/j.1398-9995.2010.02340.x) have characterized the nasal mucosa of Chinese subjects with moderate/severe persistent (PER) or intermittent (IAR) allergic rhinitis. Nasal tissue from both subjects with IAR and those with PER showed increased eosinophil and mast cell numbers compared with those seen in nonallergic subjects, with exaggerated conditions in PER tissues compared with those seen in IAR tissues. The authors also demonstrated that eosinophil and mast cell activation markers, such as IL-5 and leukotrienes, respectively, were found in much higher concentration in PER and IAR tissues, implying a distinct Th2 inflammatory profile.

Corresponding author Shixi Liu, PhD, MD, had this to add: “This is the first study to describe the inflammatory cell and mediator signatures in patients with PER versus IAR, using the new ARIA classification. The study shows that PER and IAR can not only be distinguished clinically but also are different in terms of the degree of eosinophilic inflammation and mast cell response to anti-IgE. These observations support the concept of classification.

Tell us what you think. Please feel free to post your own comments below. Topics and articles that you think would be of interest in our NBOP section and/or this blog can be sent to the JACI Editorial Office at jaci@njhealth.org.

3 comments:

  1. I am AMANDA KARIPETRA living in USA, i have be suffering from Herpes,for
    many
    years, period of 7year,without cure. on one faithful day i saw an
    article on the internet were a woman talked about doctor ISE and how this
    doctor cured her permanently of HIV.
    I contacted him through his email : ISESPIRITUALSPELLTEMPLE@GMAIL.COM and told
    him of my illness. This grate man cured my Herpes infection disease. He
    sent me herbal medicine that healed me completely. Today I`m living
    happily and free from HERPES. I have concluded on my mind that there is no
    cure, he is the owner and founder of ISE HERB RESEARCH CENTRE[IHRC]
    Dr .ISE have the cure for HIV, Zika,HPV,ASTHMA,Diabetes,syphilis,low sperm
    count,cancer,madness,hepatitis,bacteria and parasitic infection and
    other related viral infection. He had spend 15 year's in practicing
    spiritualism,consultants, using herbs and spiritual means to cure
    illness all over the world. The main reason i am writing this testimony is
    to inform the whole world about his great deeds,and he is a Herbal Doctor
    who can cure deadly diseases. He is also a great spell caster I had not
    see any Doctor so powerful like this grate man,he had save many life.
    You can contact him via; ISESPIRITUALSPELLTEMPLE@GMAIL.COM
    or BROWNYALEXY@GMAIL.COM +2348151978888....
    Add me on face book:Kari Petra

    ReplyDelete
  2. few week ago I felt some pains and I went to the hospital my doc told me I had hpv about 1 yr and I need to start the treatment early, he gave me some medicine to be taking and I told him no I’ll not, because I hated taking medicine when I won’t not see cure for the purpose. After I got home I started getting worried searching for strong advice and I found valid natural treatment online lot people says they got hpv cure from Dr onokun and I email Dr Onokun 3 days passed, I purchase his cure online some weeks after the process taking his treatment i got cured. I went for checkup twice after taking the natural treatment from the herbalist called Dr onokun and i tested negative. contact him on email: Dronokunherbalcure@gmail.com

    ReplyDelete
  3. I was diagnosed of HERPES in 2015, i have tried everything possible in life from one doctor to another, one hospital to another, series of tests different kinds of medication i had already lost hope until i meet Great DR OBUDU online testimonies, a specialist in herbal medication from Africa, i contacted him true his email OBUDU.MIRACLEHERBALHOME@GMAIL.COM and he prepared HERPES herbal medication for me which i took for 14days and now i am completely cured i want to use this medium to express my gratitude to him for saving my life and curing me from HERPES VIRUS for taking away all my pains and sorrows, I''m indeed grateful and i am so happy I''m now cured totally, I will continue to tell the good news of your great works to everyone, if you have HERPES or other disease contact him true his Email: OBUDU.MIRACLEHERBALHOME@GMAIL.COM Or whatsApp him via +2347035974895 thank you my great DR OBUDU for curing me keep up your great work

    ReplyDelete